Must-Try U.S. 1 Restaurants: The Best Restaurants on the Overseas Highway in the Florida Keys

What’s a road trip without delicious food? The 113-mile-long Overseas Highway is one of the most scenic stretches of road in the country, and it just so happens to have plenty of good local eats along the way. From Key Largo to Key West, here are just some of the best restaurants and food stops worthy of your appetite on the Overseas Highway (U.S. 1). Happy eating!

Mrs. Mac’s Kitchen II

The longest running restaurant in Key Largo has been a beloved Keys establishment since the 1970s, when founder Jeff MacFarland opened the place as a way to celebrate his mother’s famous recipes. You’ll find simple no-frills home-style cooking here, with a Keys twist of course. Dishes like the Florida lobster bites, world-famous chili, and award-winning “konk” chowder earned Mrs. Mac’s Kitchen II “The Best” in the People’s Choice Awards and “Best Hometown Café" along with numerous other awards and acknowledgements. 99020 Overseas Hwy, Key Largo

Blond Giraffe Key Lime Pie Factory

Blond Giraffe isn’t a restaurant per se, but if you enjoy a slice of pie on their outdoor patio for breakfast, lunch, or dinner, we think it counts! Their award-winning key lime pie has been praised by Food Network and Travel Channel, and was even voted “Best in Florida” by Florida Monthly Magazine. The Key Largo pie factory serves up classic and unique versions of their famous key lime pie, as well as chocolate dipped frozen key lime pie on a stick, key lime pie cookies, meringues, candies, and key lime rum cakes. 92220 Overseas Hwy, Tavernier

M.E.A.T.

M.E.A.T. Eatery and Taproom is known for its in-house smoked meats and "adult milkshakes" made with craft beer and homemade ice cream, but the main draw to this Islamorada restaurant is their award-winning burger. It is so popular in fact, that Reader’s Digest named it the No. 1 burger in the entire state. M.E.A.T’s Nancy Pants with Cheese is made with farm-fresh ingredients and a mouthwatering blend of short rib, chuck, and brisket. The burger is cooked in bacon and duck grease on a flat top and sprinkled with a special seasoning, giving it its signature crust. 88005 Overseas Hwy, Marathon

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Tacos Jalisco at Florida Keys Brewing Co.

For a pit stop about halfway through your Overseas Highway best restaurant road trip, stop in for a local craft beer at the Florida Keys Brewing Co. Try the Iguana Bait, a local honey and hibiscus-infused kolsch (local iguanas love hibiscus). For grub, stop at the Tacos Jalisco food truck in the brewery’s beer garden. Their fresh authentic Mexican dishes include tacos, burritos, and much more with proteins like chorizo, al pastor, lengua, pescado, pollo, and camarón. 81611 Old Hwy, Islamorada

Hungry Tarpon Restaurant

While Hungry Tarpon’s Keys-style dishes served alfresco are the slice of island life you’ve been looking for, it’s the world-famous tarpon feeding that brings visitors back again and again. Pay for a bucket of fish at Robbie’s Marina to watch the “silver kings” jump out of the water and claim their food. The huge fish reach sizes of 8 feet and can weigh up to 280 pounds, so it’s always a spectacle! Try Hungry Tarpon’s tuna sliders, mahi reuben, or BYOF (bring your own fish) to have them prepare your fresh catch grilled, blackened, fried, or Thai-style. 77522 Overseas Hwy, Islamorada

No Name Pub

The historic No Name Pub is about a five-minute detour from the Overseas Highway, but a visit to the “best casual dining experience in the Florida Keys” is totally worth it. The iconic tavern’s interior is bedecked from floor to ceiling with dollar bills and the menu includes eclectic pub pizzas, homemade smoked yellowfin tuna dip, and more Florida seafood-centric dishes. 30813 Watson Blvd, Big Pine Key

Blue Heaven

You’ve reached the end of the road in Key West, and we think it’s where the fun really starts. Just a quarter of a mile from the green mile marker zero sign, you’ll find Blue Heaven, a whimsical place with chickens and cats roaming, canopies of tropical foliage, improvised art, and delicious eats - breakfast through dinner - with a Caribbean twist. Try the Key West shrimp eggs benedict, Caribbean BBQ shrimp, or sautéed yellowtail snapper with a citrus beurre blanc sauce and tropical fruit. 729 Thomas St, Key West

After eating your way through the best restaurants on the Overseas Highway, you’ll need a place to put your feet up. Book your stay on the best island in the U.S. See the best rates at 24 North Hotel Key West here.

Stay up to date with our events calendar for the best in Key West entertainment, including our brand new Pet Yoga and Paint & Sip series, held monthly.

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